Ocular Findings in Japanese Children with Nephrotic Syndrome Receiving Prolonged Corticosteroid Therapy

Vol. 220, No. 3, 2006

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Original Paper

Ocular Findings in Japanese Children with Nephrotic Syndrome Receiving Prolonged Corticosteroid Therapy
Yoriko Hayasaka^a, Seiji Hayasaka^a, Hiroyoshi Matsukura^{b, c}

Departments of
^aOphthalmology and
^bPediatrics, Toyama Medical and Pharmaceutical University, and
^cDivision of Pediatrics, Saiseikai Toyama Hospital, Toyama, Japan

Address of Corresponding Author

Ophthalmologica 2006;220:181-185 (DOI: 10.1159/000091762)

Key Words

Nephrotic syndrome
Corticosteroid
Epiblepharon

Abstract

Objective: To examine ocular findings in Japanese children with nephrotic syndrome who receive prolonged corticosteroid treatment. Methods: Information was retrospectively obtained from each patient's record. Results: A total of 45 children (30 boys and 15 girls) were enrolled. Twenty-one patients (46.7%) had epiblepharon with inverted eyelashes. The incidence of epiblepharon was associated with overweight and obesity. Fifteen patients (33.3%) developed posterior subcapsular cataract in both eyes. Of the 15 patients, 4 had visual acuity less than 0.4 and underwent cataract extraction in both eyes. Nine patients (20%) developed intraocular pressure higher than 22 mm Hg during corticosteroid treatment. The total dose and duration of corticosteroid treatment were associated with cataract formation but were unassociated with elevated intraocular pressure. One boy had elevated intraocular pressure after cessation of corticosteroid therapy and underwent trabeculectomy. One patient had repeated hordeolum in the left eyelid. Three patients had bilateral bacterial conjunctivitis. Conclusion: Children with nephrotic syndrome who receive corticosteroid treatment may have epiblepharon, cataract, ocular hypertension, hordeolum and bacterial conjunctivitis.

Author Contacts

Yoriko Hayasaka, MD, PhD
Department of Ophthalmology, Toyama Medical and Pharmaceutical University
2630 Sugitani
Toyama 930-0194 (Japan)
Tel. +81 76 434 7363, Fax +81 76 434 5037, E-Mail ophthal@ms.toyama-mpu.ac.jp

Article Information

Received: August 8, 2005
Accepted after revision: November 25, 2005
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 5, Number of References : 25

Medline Abstract (ID 16679793)

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