Original Paper

In Search for New Antipsoriatic Agents: NAD⁺ Topical Composition
A. Wozniacka^a, P. Szajerski^b, J. Adamus^b, J. Gebicki^b, A. Sysa-Jedrzejowska<sup>a

a</sup>Department of Dermatology, Medical University, Lodz,
^bInstitute of Applied Radiation Chemistry, Technical University, Lodz, Poland

Address of Corresponding Author

Skin Pharmacol Physiol 2007;20:37-42 (DOI: 10.1159/000096170)

  Key Words

• Nicotinamide adenine dinucleotide
• Psoriasis
• Antipsoriatic therapy

  Abstract

The aim of the study was to examine the effectiveness of the oxidized form of nicotinamide adenine dinucleotide (NAD⁺), adenosine precursor, in 37 patients suffering from psoriasis. As NAD⁺ is known to be relatively unstable, the second goal was to establish the proper conditions for the satisfactory stability of topical NAD⁺ composition. In each patient, two matching plaques were selected for the study. Topical treatment with 1 or 0.3% NAD⁺ in Vaseline ointment administered twice daily was compared with overnight therapy with 0.1% anthralin applied for 12 h and placebo. The enzymatic method was applied to determine the stability of NAD⁺ in Vaseline ointment. After a 4-week application, the reduction in erythema, infiltration and desquamation caused by 1 or 0.3% topical NAD⁺ composition was similar to the reduction caused by 0.1% anthralin. It was demonstrated that NAD⁺ underwent a considerable decomposition at room temperature, while it was sufficiently stable at 5°C; thus, for a longer use the agent should be stored at fridge temperature. NAD⁺ therapy combines good efficacy, cosmetic acceptability and convenient twice-daily application.

Copyright © 2007 S. Karger AG, Basel

  Author Contacts

Wozniacka Anna MD, PhD
Department of Dermatology, Medical University of Lodz
Krzemieniecka 5
PL-94-017 Lodz (Poland)
Tel./Fax +48 42 688 45 65, E-Mail wozniacka@bmp.net.pl

  Article Information

Received: September 29, 2005
Accepted after revision: April 21, 2006
Published online: October 11, 2006
Number of Print Pages : 6
Number of Figures : 4, Number of Tables : 2, Number of References : 24