Pharmacokinetics of Imipenem in Sheep with Special Reference to Its Hepato-Renal Effects

Vol. 53, No. 3, 2007

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Pharmacology

Pharmacokinetics of Imipenem in Sheep with Special Reference to Its Hepato-Renal Effects
K. Abo EL-Sooud^a, W. Khammas^b, M. Nadir Kadri^b

^aDepartment of Veterinary Medicine, Faculty of Agriculture and Veterinary Medicine, Qassim University, Buraidah, Saudi Arabia;
^bDepartment of Veterinary Basic Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid, Jordan

Address of Corresponding Author

Chemotherapy 2007;53:169-172 (DOI: 10.1159/000100810)

Key Words

Electron microscopy
Hepato-renal effects
Imipenem
Pharmacokinetics

Abstract

Background: Imipenem is a carbapenem antibiotic with a broad spectrum of activity. The aim of this study was to determine the pharmacokinetics of imipenem after single intravenous and intramuscular injections and the effect of repeated intramuscular injections on hepato-renal functions in sheep. Methods: Imipenem concentrations in plasma and urine were determined by a microbiological agar plate assay. Results: Following intramuscular injection, imipenem was rapidly absorbed and the peak plasma concentration was 9.99 µg ml^-1 and the systemic bioavailability was 65.97%. Urine concentrations of imipenem were much higher than in plasma. Light and electron microscopy evidenced little changes in the kidney andliver. Conclusion: Imipenem is likely to be efficacious in most urinary tract infections and has no adverse effects on hepato-renal structures and functions.

Author Contacts

K. Abo EL-Sooud
Department of Veterinary Medicine, Faculty of Agriculture and Veterinary Medicine
Qassim University, P.O. Box 1482
Buraidah 51431 (Saudi Arabia)
Tel. +966 6 380 1480, Fax +966 6 380 1360, E-Mail kasooud@hotmail.com

Article Information

Presented at the 1st World Conference on Magic Bullets - EHRLICH 2004, Nürnberg, Germany, September 9-11, 2004.

Received: August 10, 2005
Accepted after revision: February 28, 2006
Published online: March 15, 2007
Number of Print Pages : 4
Number of Figures : 5, Number of Tables : 2, Number of References : 11

Medline Abstract (ID 17361077)

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