Minimally Differentiated Acute Myeloid Leukemia with t(12;22)(p13;q11) Translocation Showing Primary Multidrug Resistance and Expressing Multiple Multidrug-Resistant Proteins

Vol. 118, No. 1, 2007

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Case Report

Minimally Differentiated Acute Myeloid Leukemia with t(12;22)(p13;q11) Translocation Showing Primary Multidrug Resistance and Expressing Multiple Multidrug-Resistant Proteins
Suning Chen, Yongquan Xue, Xinghu Zhu, Yafang Wu, Jinlan Pan

Leukemia Research Unit, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, PR China

Address of Corresponding Author

Acta Haematol 2007;118:38-41 (DOI: 10.1159/000101997)

Key Words

Chromosome painting
Minimally differentiated acute myeloid leukemia
Multidrug resistance
TEL-MN1 fusion gene
t(12;22) translocation

Abstract

Here we report a rare chromosomal translocation, t(12;22)(p13;q11), which was detected in a 53-year-old female patient diagnosed as having minimally differentiated acute myeloid leukemia (AML-M0) according to the French-American-British classification criteria. Chromosome painting analysis with probes for chromosomes 12 and 22 confirmed the result of the conventional cytogenetic analysis. Reverse transcriptase polymerase chain reaction revealed the TEL-MN1 fusion transcript. Interestingly, she presented primary multidrug resistance and did not respond to several kinds of chemotherapy regimens. Moreover, she could not achieve remission after two doses of monotherapy with Mylotarg. Flow cytometry analysis detected high levels of expression of P-glycoprotein, multidrug-resistant-related protein, lung-related protein, and glutathione S-transferase in this case at presentation. As far as we know, this is the first report of t(12;22)(p13;q11) translocation involving TEL and MN1 genes in an AML-M0 patient.

Author Contacts

Dr. Yongquan Xue
Leukemia Research Unit, Jiangsu Institute of Hematology
First Affiliated Hospital of Soochow University, 296 Shizi Street
Suzhou 215006 (PR China)
Tel. +86 512 6778 0471, Fax +86 512 6519 2662, E-Mail yanmiz@vip.sohu.net

Article Information

Received: January 3, 2006
Accepted after revision: February 21, 2007
Published online: April 27, 2007
Number of Print Pages : 4
Number of Figures : 3, Number of Tables : 0, Number of References : 13

Medline Abstract (ID 17476096)

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