Review Article

Is Antioxidant Therapy a Viable Alternative for Mild Cognitive Impairment? Examination of the Evidence
Marie-Laure Ancelin^a, Yves Christen^b, Karen Ritchie<sup>a

a</sup>Inserm, U888, University of Montpellier-1, Montpellier, and
^bIpsen, Paris, France

Address of Corresponding Author

Dement Geriatr Cogn Disord 2007;24:1-19 (DOI: 10.1159/000102567)

  Key Words

• Oxidative stress
• Antioxidants
• Vitamins
• Ginkgo biloba
• Mild cognitive impairment
• Alzheimer's disease

  Abstract

Therapeutic interventions for the prodromal stages of dementia are currently being sought with a view to delaying if not preventing disease onset. Uncertainty as to whether cognitive disorder in a given individual will progress towards dementia and adverse drug side effects has led to hesitancy on the part of drug regulators to instigate preventive pharmacotherapies. In this context, antioxidant therapies may provide a low-risk alternative, targeting very early biological changes. While a growing body of knowledge demonstrates both the importance of oxidative stress in the aetiology of dementia and the efficacy of antioxidant treatment in animal and cellular models, studies in humans are presently inconclusive. While some antioxidants, notably flavonoid- or vitamin-rich diets, appear to lower the relative risk for Alzheimer's disease in humans in observational studies, these results must be interpreted in the light of the biological complexity of the relationship between oxidative stress and neurodegeneration, and the methodological and theoretical shortcomings of studies conducted to date. A clearer understanding of these factors will assist in the interpretation of the results of the intervention studies which are now being undertaken; these studies being the only current means of establishing efficacy for preventive drug treatment of Alzheimer's disease.

Copyright © 2007 S. Karger AG, Basel

  Author Contacts

Dr. Yves Christen
24 rue Erlanger
FR-75016 Paris (France)
Tel. +33 144 96 1010, Fax +33 144 96 1199 E-Mail yves.christen@ipsen.com

  Article Information

Y.C. is an employee of Ipsen.

Accepted: January 18, 2007
Published online: May 10, 2007
Number of Print Pages : 19
Number of Figures : 0, Number of Tables : 2, Number of References : 188