Association of MDR1 (C3435T) Polymorphism and Resistance to Carbamazepine in Epileptic Patients from Turkey

Vol. 59, No. 1-2, 2008

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Original Paper

Association of MDR1 (C3435T) Polymorphism and Resistance to Carbamazepine in Epileptic Patients from Turkey
Gulay Oner Ozgon^a, Nerses Bebek^{a, b}, Gunay Gul^c, Naci Cine^a

^aDepartment of Genetics, Institute for Experimental Medical Research and
^bDepartment of Neurology, Istanbul Medical Faculty, Istanbul University and
^c3rd Department of Neurology, Bak inodot rkoy State Hospital for Neurology and Psychiatric Diseases, Istanbul, Turkey

Address of Corresponding Author

Eur Neurol 2008;59:67-70 (DOI: 10.1159/000109264)

Key Words

Epilepsy
Drug resistance
Polymorphism
Carbamazepine
MDR1

Abstract

Background and Aims: We investigated the prevalence of this multidrug resistance 1 gene (MDR1) polymorphism in drug-responsive versus drug-resistant epilepsy patients treated with carbamazepine (CBZ), which is a substrate of this protein. Methods: We genotyped the C3435T variant of MDR1 in 97 patients treated with CBZ monotherapy who had been on stable doses for more than 1 month. Our control group included 174 healthy individuals. Plasma CBZ concentrations were also measured using fluorescence polarization immunoassay. Results: We could not demonstrate any statistically significant relationship with the genotypes among drug-resistant patients (n = 44). The frequency of the homozygous mutant (TT) genotype was 15% in drug-responsive patients, 11.3% in drug-resistant patients and 25.8% in the control group. We also did not observe any significant correlation between the presence of a specific allele and CBZ plasma level/dose index. Conclusion: Our study did not support any significant association between the MDR1 (C3435T) polymorphism and resistance to CBZ in epilepsy patients from Turkey.

Author Contacts

Nerses Bebek, MD, Department of Genetics
Institute for Experimental Medical Research (DETAE), Istanbul University
Vakif Gureba Cad. Capa, TR-34093 Istanbul (Turkey)
Tel. +90 212 631 13 51, ext. 122, Fax +90 212 631 13 51, ext. 113
E-Mail nersesb@yahoo.com

Article Information

This work was presented in part as a poster at the 6th European Congress on Epileptology, Vienna, 2004.

G.O. Ozgon and N. Bebek contributed equally to this study.

Received: November 22, 2006
Accepted: May 7, 2007
Published online: October 4, 2007
Number of Print Pages : 4
Number of Figures : 0, Number of Tables : 2, Number of References : 15

Medline Abstract (ID 17917461)

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