Original Paper

Does Sildenafil Affect Uroflowmetry Values in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Enlargement?
Cem Güler, Emre Tüzel, Engin Doantekin, Güne Kzltepe

Department of Urology, Afyon Kocatepe University School of Medicine, Afyon, Turkey

Address of Corresponding Author

Urol Int 2008;80:181-185 (DOI: 10.1159/000112611)

  Key Words

• Benign prostate enlargement
• Sildenafil
• Uroflowmetry
• Phosphodiesterase inhibitors

  Abstract

Aims: To investigate the effect of sildenafil on uroflowmetry values of patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic enlargement (BPE). Methods: Thirty-eight consecutive patients and 15 control subjects without voiding symptoms were enrolled in the study. All patients underwent uroflowmetry testing thrice on different occasions. The highest maximum urinary flow rate (Q_max) values with a sufficient voided volume (150 ml) were evaluated. The patients and controls were seen the day after the initial uroflowmetry measurements and were given 100 mg sildenafil. Afterwards uroflowmetry was repeated. The uroflowmetry values of both groups before and after sildenafil were compared. Results: Of the 38 patients, 29 (76%) showed improvement in flow rates. The mean Q_max was 11.4 ± 0.39 and 15.7 ± 0.74 ml/s before and after sildenafil, respectively (p < 0.0001). The mean percentage difference in Q_max was +38% higher after sildenafil. The mean average flow rate (Q_ave) and the mean voiding time values were also significantly improved. The mean voided volumes of the patients before and after sildenafil were 241 ± 78 and 264 ± 72 ml, respectively (p = 0.07). There were no significant differences in the Q_max, Q_ave and voided volumes of the control group. Conclusions: Sildenafil exhibits a significant improvement in Q_max and Q_ave rates in men with LUTS.

Copyright © 2008 S. Karger AG, Basel

  Author Contacts

Assist. Prof. Dr. Emre Tüzel Ordu Bulvar, Bereket Apt. No. 17/5 Kat. 2
TR-03200 Afyon (Turkey)
Tel. +90 272 214 20 61, Fax +90 272 213 30 66
E-Mail emretuzel@aku.edu.tr

  Article Information

Received: October 17, 2006
Accepted after revision: April 27, 2007
Published online: March 19, 2008
Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 1, Number of References : 20