Research Article

Detection of Human Papillomavirus DNA by DNA Chip in Breast Carcinomas of Korean Women
Yoon-La Choi^a, Eun Yoon Cho^a, Jung Han Kim^b, Seok Jin Nam^b, Young Lyun Oh^a, Sang Yong Song^a, Jung-Hyun Yang^b, Dae Shick Kim<sup>a

a</sup>Department of Pathology and
^bDivision of Breast-Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Address of Corresponding Author

Tumor Biol 2007;28:327-332 (DOI: 10.1159/000124238)

  Key Words

• Breast cancer
• Chip
• HPV DNA chip typing
• Papillomavirus, human

  Abstract

It remains unclear whether there is an association between human papillomavirus (HPV) infection and human breast cancer. The aim of this study was to investigate the presence of HPV DNA in breast carcinomas of Korean women and to examine the possible association between HPV and breast cancer development. For this purpose, HPV DNAs from 154 patients, including 123 patients with breast carcinoma and 31 with intraductal papilloma, and nipple tissue from 27 cancer patients were examined using the DNA chip method. HPV DNA was detected in 8 breast carcinomas (6.5%) but in no intraductal papilloma. All detected HPV genotypes were of high-risk groups. There was a slightly increased incidence in papillary carcinomas (11.5%) and invasive ductal carcinomas with adjacent intraductal papillomas (11.8%) compared to the other histological subtypes (3.2-4.3%), although the difference was not statistically significant (p = 0.126). The presence of HPV DNA was not correlated with specific prognostic predictors of disease. High-risk HPV DNA sequences were present in 6.5% of Korean patients with breast tumors. However, this study could not demonstrate whether or not such HPVs directly contribute to the development of breast cancer.

Copyright © 2008 S. Karger AG, Basel

  Author Contacts

Dae Shick Kim, MD, PhD
Department of Pathology, Samsung Medical Center
Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Gu
Seoul, 135-710 (Korea)
Tel. +82 2 3410 2764, Fax +82 2 3410 0025, E-Mail dspro.kim@samsung.com

  Article Information

Yoon-La Choi and Eun Yoon Cho contributed equally to the study.

Received: August 15, 2007
Accepted after revision: November 16, 2007
Published online: April 4, 2008
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 2, Number of References : 31