SNP detection and comparative linkage mapping of 66 bone-related genes in the pig

Vol. 122, No. 2, 2008

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Original Article

SNP detection and comparative linkage mapping of 66 bone-related genes in the pig
S.K. Onteru^a, B. Fan^a,b, M.F. Rothschild^a

^aDepartment of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA (USA)
^bKey Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan (People's Republic of China)

Address of Corresponding Author

Cytogenet Genome Res 2008;122:122-131 (DOI: 10.1159/000163089)

Abstract.

Osteoporosis is a multigenic complex disorder. Though the mouse and rat are used as experimental models for human osteoporosis, the pig bone remodeling cycle is histologically more similar to human than the rat or mouse. Moreover, livestock genomics have many advantages over model organisms and human studies for complex trait dissection. Hence, in the present work 66 bone-related genes were newly genetically mapped on pig chromosomes. Comparative chromosomal patterns of bone-related genes in the pig, human, mouse and rat provide clues that the chromosomal organization of bone-related genes in pigs is more similar to human than that of the mouse and rat. Therefore, the pig can be considered as one of the better models for studying the molecular genetics of bone-related disorders.

Author Contacts

Request reprints from Max F. Rothschild
Department of Animal Science and
Center for Integrated Animal Genomics, Iowa State University
2255 Kildee Hall, Ames, IA 50011 (USA)
telephone: +1 515 294 2570; fax: +1 515 294 2401
e-mail: mfrothsc@iastate.edu

Article Information

Fundings provided by the National Pork Board, Iowa Board of Regents, The College of Agriculture and Life Sciences, Hatch and State of Iowa Funds are greatly appreciated.

Accepted in revised form for publication by K.M. Reed,: 16 June 2008.
Published online: December 18, 2008
Number of Print Pages : 10
Number of Figures : 1, Number of Tables : 3, Number of References : 88

Medline Abstract (ID 19096207)

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