Apolipoprotein (a) Levels and Atherogenic Lipid Fractions in Relation to the Degree of Urinary Albumin Excretion in Type 2 Diabetes mellitus

Vol. 66, No. 3, 1994

Free Abstract Article (PDF 2570 KB)

Original Paper

Apolipoprotein (a) Levels and Atherogenic Lipid Fractions in Relation to the Degree of Urinary Albumin Excretion in Type 2 Diabetes mellitus
Christoph Schnack, Peter Pietschmann, Paul Knöbl, Elisabeth Schuller, Rudolf Prager, Guntram Schernthaner

Department of Medicine II, University of Vienna and Department of Medicine I, Rudolfstiftung Hospital, Vienna, Austria

Address of Corresponding Author

Nephron 1994;66:273-277 (DOI: 10.1159/000187822)

Key Words

Diabetes mellitus
Diabetic nephropathy
Microalbuminuria
Lipid abnormalities
Apolipoprotein (a)

Abstract

The relationship between serum lipids, apolipoprotein levels including apolipoprotein (a) to albumin excretion rate (AER) in 52 (17 male, 35 female) type 2 diabetic patients was studied. Patients were classified in groups as follows: (1) patients with normal AER ( < 30 mg/24 h); (2) patients with microalbuminuria (AER 30-300 mg/24 h), and (3) patients with macroalbuminuria (AER > 300 mg/24 h). Apolipoprotein B levels were significantly (p < 0.05) elevated in the patients with macroalbuminuria compared to the normoalbuminuric group. Further, we observed a significant correlation between total cholesterol, low-density lipoprotein cholesterol, as well as apolipoprotein B levels to the degree of AER. No correlation between apolipoprotein (a) levels and AER, which is in contrast to recently published data for type 1 diabetic patients, was found. Systolic blood pressure was significantly higher (p < 0.002) in the patients with micro- and macroalbuminuria compared to the group with normal albumin excretion, whereas no relationship between diastolic blood pressure and albuminuria was found. We conclude that elevated increased atherogenic lipid fractions in addition to systolic hypertension may contribute to an increased cardiovascular risk in type 2 diabetic patients with proteinuria.

Author Contacts

Prof. G. Schernthaner, Rudolfstiftung Hospital, Juchgasse 25, A-1030 Wien (Austria)

Article Information

Accepted: February 26, 1993
Published online: December 16, 2008
Number of Print Pages : 5

This journal is part of the third subject package of the Karger

Journal Archive Collection

Information on packages (PDF)
Free sample issues

For non-native English speakers and international authors who would like assistance with their writing before submission, we suggest American Journal Experts for their scientific editing service.