Bone Mineral Density in Patients with Hypercalciuric Nephrolithiasis

Vol. 73, No. 4, 1996

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Original Paper

Bone Mineral Density in Patients with Hypercalciuric Nephrolithiasis
J.R. Zanchetta, G. Rodríguez, A.L. Negri, E. del Valle, F.R. Spivacow

Metabolic Research Institute, Buenos Aires, Argentina

Address of Corresponding Author

Nephron 1996;73:557-560 (DOI: 10.1159/000189140)

Key Words

Idiopathic hypercalciuria
Bone mineral density
Renal lithiasis
Calcium balance

Abstract

Bone mineral density was studied in 50 adult patients with renal lithiasis and metabolic diagnosis of idiopathic hypercalciuria. Thirty were premenopausal women and 20 were men under 55 years of age. Bone density at the lumbar spine (LSBD) was 0.940 ± 0.106 g/cm² in the hypercalciuric patients compared to 1.112 ± 0.037 g/cm² in a cohort of age- and sex-matched controls (p < 0.001). LSBD was independent of age and was negatively correlated with the duration of stone disease (r = -0.52, p < 0.001). Thus we conclude that patients with idiopathic hypercalciuria have a decrease in their LSBD that is probably related to a negative calcium balance sustained over time.

Author Contacts

José Rubén Zanchetta, MD, Instituto de Investigaciones Metabólicas, Libertad 836 1 piso, Buenos Aires 1012 (Argentina)

Article Information

Accepted: August 14, 1995
Published online: December 19, 2008
Number of Print Pages : 4

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