1 ,5-Anhydroglucitol as a Marker for the Differential Diagnosis of Acute and Chronic Renal Failure

Vol. 73, No. 4, 1996

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Short Communication

1 ,5-Anhydroglucitol as a Marker for the Differential Diagnosis of Acute and Chronic Renal Failure
Hideo Yamada^a, Akira Hishida^b, Akihiko Kato^b, Takashi Yoneyama^a

^aDepartment of Internal Medicine, Kanbara Municipal Hospital,
^bFirst Department of Internal Medicine, Hamamatsu University, School of Medicine,
^cDepartment of Internal Medicine, Hamamatsu Rousai Hospital, and
^dDepartment of Internal Medicine, Seirei Hamamatsu General Hospital, Shizuoka, Japan

Address of Corresponding Author

Nephron 1996;73:707-709 (DOI: 10.1159/000189166)

Key Words

1,5-Anhydroglucitol
Acute renal failure
Chronic renal failure

Abstract

Serum creatinine and 1,5-anhydroglucitol (1,5-AG) were measured in 21 non-dialysis acute renal failure (ARF) and 32 chronic renal failure (CRF) patients. Fasting blood glucose was under 100 mg/dl and no patient had a history of diabetes mellitus. Serum 1,5-AG decreased with increase in serum creatinine in CRF, but not in ARF patients. A significant negative correlation was found between serum 1,5-AG and creatinine in CRF patients (r = -0.592, p < 0.001). Serum 1,5-AG in patients with serum creatinine of 4 mg/dl or more was less than the lowest limit of the normal range in 14 of 15 CRF patients, but only 2 of 12 ARF patients. In these 27 patients, serum 1,5-AG was significantly higher in ARF than CRF (19.0 ± 5.9 vs. 7.2 ± 4.1 µg/ml, p < 0.01). From these results, it would follow that serum 1,5-AG should serve effectively as a marker for the differential diagnosis of nondiabetic ARF and CRF.

Author Contacts

Dr. Hideo Yamada, Department of Internal Medicine, Kanbara Municipal Hospital, Nakanogou 2500-1, Fujikawa-chou, Ihara-gun, Shizuoka 421-33 (Japan)

Article Information

Accepted: August 30, 1995
Published online: December 19, 2008
Number of Print Pages : 3

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