Researchers’ Perceptions of the Ethical Implications of Pharmacogenomics Research with Children

Vol. 12, No. 3, 2009

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Original Paper

Researchers' Perceptions of the Ethical Implications of Pharmacogenomics Research with Children
D. Avard, T. Silverstein, G. Sillon, Y. Joly

Centre de recherche en droit public, Law Faculty, Université de Montréal, Montréal, Qué., Canada

Address of Corresponding Author

Public Health Genomics 2009;12:191-201 (DOI: 10.1159/000189633)

Key Words

Ethical
Health professionals
Pediatric
Perceptions
Pharmacogenomics
Research
Social

Abstract

Background: This paper presents the results of an exploratory qualitative study that assesses Canadian pediatric researchers' perceptions of a pre-selected group of ethical issues raised by pharmacogenomics research with children. Methods: As a pilot study, we conducted semi-structured telephone interviews with Canadian pediatric pharmacogenomic researchers. The interviews were guided by the following themes: (1) benefits and risks of inclusion, (2) the consent/assent process, and (3) the return of research results. Results: Issues about assent, consent, risks and benefits, as well as the communication of results were addressed by the respondents. Some issues, such as the unique vulnerability of children, the long term privacy concerns associated with biobanking, additional core elements that need to be discussed and included in the consent/assent forms, as well as the challenges of communicating research results in a pediatric research were not explicitly identified by the respondents. Conclusion: Further consideration should be given to address the ethical challenges of including children in pharmacogenomics research. This exploratory study indicates that further guidance is needed if children are to be protected and yet benefit from such research.

Author Contacts

Denise Avard
Centre de recherche en droit public, Faculté de Droit
C.P. 6128, succ. Centre-ville, Montréal, Qué., H3C 3J7 (Canada)
Tel. +1 514 343 7702, Fax +1 514 481 6144
E-Mail denise.avard@umontreal.ca

Article Information

Published online: February 10, 2009
Number of Print Pages : 11
Number of Figures : 0, Number of Tables : 2, Number of References : 45

Medline Abstract (ID 19204423)

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