A Case of Mania following Deep Brain Stimulation for Obsessive Compulsive Disorder

Vol. 88, No. 5, 2010

Article (References) Article (PDF 327 KB)

Case Report

A Case of Mania following Deep Brain Stimulation for Obsessive Compulsive Disorder
Ihtsham U. Haq^a, Kelly D. Foote^c, Wayne K. Goodman^{b, d}, Nicola Ricciuti^d, Herbert Ward^d, Atchar Sudhyadhom^e, Charles E. Jacobson^f, Mustafa S. Siddiqui^a, Michael S. Okun^{c, d, f}

^aDepartment of Neurology, Wake Forest University Health Sciences, Winston-Salem, N.C.,
^bDepartment of Psychiatry, Mount Sinai Medical Center, New York, N.Y., and Departments of
^cNeurosurgery,
^dPsychiatry,
^eNuclear and Radiological Sciences and
^fNeurology, McKnight Brain Institute, University of Florida, Gainesville, Fla., USA

Address of Corresponding Author

Stereotact Funct Neurosurg 2010;88:322-328 (DOI: 10.1159/000319960)

Key Words

Obsessive compulsive disorder
Deep brain stimulation, side effects
Neuropsychiatric mania

Abstract

Deep brain stimulation (DBS) of the basal ganglia is an effective treatment for select movement disorders, including Parkinson’s disease, essential tremor and dystonia. Based on these successes, DBS has been explored as an experimental treatment for medication-resistant neuropsychiatric disease. During a multiyear experience employing DBS to treat patients for obsessive compulsive disorder (OCD) we encountered several unanticipated stimulation-induced psychiatric side effects. We present a case of a young woman treated for OCD with DBS of the anterior limb of the internal capsule and nucleus accumbens region, who subsequently manifested a manic episode. We aim to discuss the case details, treatment and potential neuroanatomical underpinnings of this response.

Author Contacts

Ihtsham ul Haq, MD
Department of Neurology, Wake Forest University Health Sciences
Medical Center Boulevard
Winston-Salem, NC 27157 (USA)
Tel. +1 336 716 9494, Fax +1 336 716 9489, E-Mail ihaq@wfubmc.edu

Article Information

Received: September 23, 2009
Accepted after revision: April 11, 2010
Published online: August 13, 2010
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 1, Number of References : 37

Cited in Web of Science®

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