Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

Vol. 222, No. 2, 2011

Article (Fulltext) Article (PDF 467 KB)

Case and Review

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?
M.B. Abdel-Naser^a, F. Tsatsou^a, S. Hippe^b, J. Knolle^b, I. Anagnostopoulos^c, H. Stein^c, C.C. Zouboulis^a

^aDepartments of Dermatology, Venereology, Allergology and Immunology and
^bInstitute of Pathology, Dessau Medical Center, Dessau, and
^cInstitute of Pathology and Reference Center for Hematopathology, Charité, Medical University Berlin, Berlin, Germany

Address of Corresponding Author

Dermatology 2011;222:113-118 (DOI: 10.1159/000325460)

Key Words

Eosinophilic ulcer
CD30+ cells
Epstein-Barr virus
Oral mucosa

Abstract

Eosinophilic ulcer of the oral mucosa is a benign lesion of unclear pathogenesis mostly affecting the tongue. It has been suggested to represent a reactive pattern to several stimuli. We report on a 12-year-old boy who presented with a painless infiltrating ulcer on the gingiva of the lower jaw, which was covered by necrotic yellowish slough. There were no pathologic features of the jawbones or regional lymph nodes. Histopathological, immunohistochemical and gene rearrangement studies were in agreement with eosinophilic ulcer with predominant oligoclonal CD3+ and CD30+ T lymphocytes expressing the Epstein-Barr virus membrane protein. The ulcer resolved within 4 weeks and follow-up for 3 years revealed no evidence of recurrence. Epstein-Barr virus may have played a role in triggering this reactive lymphoproliferative disorder.

Author Contacts

Prof. Dr. Christos C. Zouboulis
Departments of Dermatology, Venereology, Allergology and Immunology
Dessau Medical Center, Auenweg 38
DE–06847 Dessau (Germany)
Tel. +49 340 5014 000, E-Mail christos.zouboulis@klinikum-dessau.de

Article Information

M.B. Abdel-Naser is a scholar of the Deutsche Forschungsgemeinschaft (DFG).

Received: April 13, 2010
Accepted after revision: February 7, 2011
Published online: April 5, 2011
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 1, Number of References : 50

Cited in Web of Science®

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