Chitosan Nanoparticles Affect the Acid Tolerance Response in Adhered Cells of <i>Streptococcus mutans</i>

Vol. 45, No. 6, 2011

Article (Fulltext) Article (PDF 316 KB)

Short Communication

Chitosan Nanoparticles Affect the Acid Tolerance Response in Adhered Cells of Streptococcus mutans
J. Neilands^a, D. Sutherland^b, A. Resin^b, P.L. Wejse^c, L.E. Chávez de Paz^a

^aDepartment of Oral Biology, Faculty of Odontology, Malmö University, Malmö, Sweden;
^bInterdisciplinary Nanoscience Center (iNANO), Faculty of Science, Aarhus University, Aarhus, and
^cArla Foods Ingredients R&D, Nørre Vium, Denmark

Address of Corresponding Author

Caries Res 2011;45:501-505 (DOI: 10.1159/000331206)

Key Words

Acid tolerance
Biofilms
Chitosan
Nanoparticles
Streptococcus mutans

Abstract

In this study we evaluated the effect of chitosan nanoparticles on the acid tolerance response (ATR) of adhered Streptococcus mutans. An ATR was induced by exposing S. mutans to pH 5.5 for 2 h and confirmed by exposing the acid-adapted cells to pH 3.5 for 30 min, with the majority of cells appearing viable according to the LIVE/DEAD® technique. However, when chitosan nanoparticles were present during the exposure to pH 5.5, no ATR occurred as most cells appeared dead after the pH 3.5 shock. We conclude that the chitosan nanoparticles tested had the ability to hinder ATR induction in adhered S. mutans.

Author Contacts

J. Neilands
Malmö University, Faculty of Odontology
Department of Oral Biology
SE–20506 Malmö (Sweden)
Tel. +46 40 665 8496, E-Mail jessica.neilands@mah.se

Article Information

Received: March 7, 2011
Accepted after revision: July 21, 2011
Published online: September 9, 2011
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 0, Number of References : 27

Cited in Web of Science®

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