Original Report: Patient-Oriented, Translational Research

Estimating Glomerular Filtration Rate Using the New CKD-EPI Equation and Other Equations in Patients with Autosomal Dominant Polycystic Kidney Disease
Bjarne Orskov^a, Malene L. Borresen^d, Bo Feldt-Rasmussen^b, Ole Østergaard^c, Inga Laursen^c, Svend Strandgaard<sup>a

a</sup>Department of Nephrology, Copenhagen University Hospital, Herlev,
^bDepartment of Nephrology, Copenhagen University Hospital, Rigshospitalet,
^cDepartment of Clinical Biochemistry and Immunology, and
^dDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

Address of Corresponding Author

Am J Nephrol 2010;31:53-57 (DOI: 10.1159/000256657)

  Key Words

• Autosomal dominant polycystic kidney disease
• Chronic Kidney Disease Epidemiology Collaboration equation
• Cockcroft-Gault equation
• Cystatin C
• Glomerular filtration rate
• Modification of Diet in Renal Disease Study equation

  Abstract

Background: No studies have compared the performance of equations for estimating glomerular filtration rate (GFR) in patients with autosomal dominant polycystic kidney disease (ADPKD), where the declining GFR typically is followed for many years or even decades. This was the purpose of the present investigation. Methods: 101 ADPKD patients with chronic kidney disease stages 1-5 were recruited and GFR was measured with the ⁵¹Cr-EDTA clearance method, and estimated with the Modification of Diet in Renal Disease Study (MDRD) equation with 4 variables, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, the Cockcroft-Gault equation adjusted for body surface area and the MDRD equation with cystatin C. Performance was evaluated by mean bias, precision and accuracy. Results: The MDRD equation with cystatin C had 97% of GFR estimates within 30% of measured GFR (accuracy). Both the CKD-EPI and Cockcroft-Gault equations had an accuracy of 90% whereas the MDRD equation had an accuracy of 83%. This difference of accuracy was especially marked with GFR >60 ml/min/1.73 m². Conclusion: For estimating GFR in ADPKD patients the MDRD equation with cystatin C incorporated had the best performance. The CKD-EPI or the Cockcroft-Gault equations showed better performance compared to the 4-variable MDRD equation.

Copyright © 2009 S. Karger AG, Basel

  Author Contacts

Bjarne Orskov
Department of Nephrology Ba54o3, Copenhagen University Hospital
Herlev Ringvej 75
DK-2730 Herlev (Denmark)
Tel. +45 4488 3781, Fax +45 4488 3709, E-Mail bjorch02@heh.regionh.dk

  Article Information

Received: August 31, 2009
Accepted: September 29, 2009
Published online: November 4, 2009
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 5, Number of References : 25