Address of Corresponding Author

Dermatology 2005;210:36-38 (DOI: 10.1159/000081481)

  Key Words

• Sebum
• Seborrhea
• Zileuton
• 5-Lipoxygenase inhibitor

  Abstract

Background: Zileuton, a 5-lipoxygenase inhibitor, reduces the number of inflammatory lesions in moderate acne and inhibits the synthesis of sebaceous lipids. Objective: To detect whether zileuton directly reduces sebum synthesis. Methods: A 40-year-old female with mild disseminated sebaceous gland hyperplasia and seborrhea was treated with zileuton 4 × 600 mg/day over 2 weeks, was followed-up for 6 weeks after discontinuation of zileuton and was re-treated with low-dose isotretinoin 10 mg/2nd day over 5 weeks. Casual skin surface lipids and sebum synthesis were determined. Results: Under treatment with zileuton increased casual skin surface lipids were normalized and synthesis of facial sebum was decreased. Six weeks after discontinuation of treatment casual skin surface lipids were increased again and synthesis of sebum returned to baseline. Subsequent low-dose isotretinoin treatment led to similar changes of casual skin surface lipids and sebum synthesis with zileuton already after 2 weeks. Conclusion: Zileuton directly inhibits sebum synthesis in a transient manner with a potency similar to low-dose isotretinoin at least in our patient.

Copyright © 2005 S. Karger AG, Basel

  Author Contacts

Prof. Dr. Christos C. Zouboulis
Department of Dermatology, Charité University Medicine Berlin
Campus Benjamin Franklin, Fabeckstrasse 60-62
DE-14195 Berlin (Germany)
Tel. +49 30 8445 6910, Fax +49 30 8445 6908, E-Mail christos.zouboulis@charite.de

  Article Information

Received: May 21, 2004
Accepted: July 2, 2004
Number of Print Pages : 3
Number of Figures : 0, Number of Tables : 1, Number of References : 8