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Research Briefings

The Neonatal European Study of Inhaled Steroids (NEUROSIS): An EU-Funded International Randomised Controlled Trial in Preterm Infants

Bassler D.a · Halliday H.L.b · Plavka R.c · Hallman M.d · Shinwell E.S.e, f · Jarreau P.-H.g · Carnielli V.h · van den Anker J.i, j · Schwab M.k, l · Poets C.F.a

Author affiliations

aDepartment of Neonatology, University Children’s Hospital, Tübingen, Germany; bRoyal Maternity Hospital, and Department of Child Health, Queen’s University, Belfast, UK; cGeneral Faculty Hospital in Prague, Prague, Czech Republic; dDepartment of Pediatrics and Adolescence and Neonatal Research Laboratory, Oulu University Hospital, University of Oulu, Oulu, Finland; eDepartment of Neonatology, Kaplan Medical Center, Rehovot, and fHebrew University, Jerusalem, Israel; gAssistance Publique-Hôpitaux de Paris, Service de Médecine Néonatale de Port-Royal and Université Paris Descartes, Paris, France; hDepartment of Paediatrics, Children’s Hospital, Azienda Ospedaliero-Universitaria, Ancona, Italy; iChildren’s National Medical Center, Washington, D.C., USA; jDepartment of Paediatrics, Erasmus MC Sophia Children’s Hospital, Rotterdam, The Netherlands; kDr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, Stuttgart, and lDepartment of Clinical Pharmacology, University Hospital Tübingen, Tübingen, Germany

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Neonatology 2010;97:52–55

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Article / Publication Details

Received: February 10, 2009
Accepted: April 21, 2009
Published online: July 07, 2009
Issue release date: December 2009

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO


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Abstract of Research Briefings

References

  1. Meadow W, Lee G, Lin K, Lantos J: Changes in mortality for extremely low birth weight infants in the 1990s: implications for treatment decisions and resource use. Pediatrics 2004;113:1223–1229.
  2. Doyle LW, Halliday HL, Ehrenkranz RA, Davis PG, Sinclair JC: Impact of postnatal systemic corticosteroids on mortality and cerebral palsy in preterm infants: effect modification by risk for chronic lung disease. Pediatrics 2005;115:655–661.
  3. Bassler D, Stoll BJ, Schmidt B, Asztalos EV, Roberts RS, Robertson CM, Sauve RS; Trial of Indomethacin Prophylaxis in Preterms Investigators: Using a count of neonatal morbidities to predict poor outcome in extremely low birth weight infants: added role of neonatal infection. Pediatrics 2009;123:313–318.
  4. Palta M, Sadek-Badawi M, Sheehy M, Albanese A, Weinstein M, McGuinness G, Peters ME: Respiratory symptoms at age 8 years in a cohort of very low birth weight children. Am J Epidemiol 2001;154:521–529.
  5. Kennedy JD, Edward LJ, Bates DJ, Martin AJ, Dip SN, Haslam RR, McPhee AJ, Strugas RE, Baghurst P: Effects of birthweight and oxygen supplementation on lung function in late childhood in children of very low birth weight. Pediatr Pulmonol 2000;30:32–40.
  6. Korhonen J, Laitinen E, Hyodynmaa E, Tammela O: Respiratory outcome in school-aged, very-low-birth-weight children in the surfactant era. Acta Paediatr 2004;93:316–321.
  7. Doyle LW, Cheung MM, Ford GW, Olinsky A, Davis NM, Callanan C: Birth weight <1,501 g and respiratory health at age 14. Arch Dis Child 2001;84:40–44.
  8. Northway WH Jr, Moss RB, Carlisle KB, Parker PR, Popp RL, Pitlick PT, Eichler I, Lamm RL, Brown BW Jr: Late pulmonary sequelae of bronchopulmonary dysplasia. N Engl J Med 1990;323:1793–1799.
  9. Bhandari V, Gruen JR: The genetics of bronchopulmonary dysplasia. Semin Perinatol 2006;30:185–191.
  10. Speer CP: Inflammation and bronchopulmonary dysplasia: a continuing story. Semin Fetal Neonatal Med 2006;11:354–362.
  11. Groneck P, Götze-Speer B, Oppermann M, Eiffert H, Speer CP: Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: a sequential analysis of inflammatory mediators in respiratory fluids of high-risk preterm neonates. Pediatrics 1994;93:712–718.
  12. Paananen R, Husa AK, Vuolteenaho R, Herva R, Kaukola T, Hallman M: Blood cytokines during the perinatal period in very preterm infants: relationship of inflammatory response and bronchopulmonary dysplasia. J Pediatr 2009;154:39–43.e3.
  13. Halliday HL, Patterson CC, Halahakoon CW; European Multicenter Steroid Study Group: A multicenter, randomized open study of early corticosteroid treatment (OSECT) in preterm infants with respiratory illness: comparison of early and late treatment and of dexamethasone and inhaled budesonide. Pediatrics 2001;107:232–240.
  14. Cole CH, Colton T, Shah BL, Abbasi S, MacKinnon BL, Demissie S, Frantz ID 3rd: Early inhaled glucocorticoid therapy to prevent bronchopulmonary dysplasia. N Engl J Med 1999;340:1005–1010.
  15. Merz U, Kusenbach G, Hausler M, Peschgens T, Hornchen H: Inhaled budesonide in ventilator-dependent preterm infants: a randomized, double-blind pilot study. Biol Neonate 1999;75:46–53.
  16. Denjean A, Paris-Llado J, Zupan V, Debillon T, Kieffer F, Magny JF, Desfrères L, Llanas B, Guimaraes H, Moriette G, Voyer M, Dehan M, Breart G: Inhaled salbutamol and beclomethasone for preventing broncho-pulmonary dysplasia: a randomised double-blind study. Eur J Pediatr 1998;157:926–931.
  17. Jónsson B, Eriksson M, Söder O, Broberger U, Lagercrantz H: Budesonide delivered by dosimetric jet nebulization to preterm very low birthweight infants at high risk for development of chronic lung disease. Acta Paediatr 2000;89:1449–1455.
  18. Jangaard KA, Stinson DA, Allen AC, Vincer MJ: Early prophylactic inhaled beclomethasone in infants less than 1250 g for the prevention of chronic lung disease. Paediatr Child Health 2002;7:13–19.
  19. Fok TF, Lam K, Dolovich M, Ng PC, Wong W, Cheung KL, So KW: Randomised controlled study of early use of inhaled corticosteroid in preterm infants with respiratory distress syndrome. Arch Dis Child Fetal Neonatal Ed 1999;80:F203–F208.
  20. Zimmerman JJ, Gabbert D, Shivpuri C, Kayata S, Miller J, Ciesielski W: Meter-dosed, inhaled beclomethasone initiated at birth to prevent bronchopulmonary dysplasia. Pediatr Crit Care Med 2000;1:140–145.
  21. Pantalitschka T, Poets CF: Inhaled drugs for the prevention and treatment of bronchopulmonary dysplasia. Pediatr Pulmonol 2006;41:703–708.
  22. Shah V, Ohlsson A, Halliday HL, Dunn MS: Early administration of inhaled corticosteroids for preventing chronic lung disease in ventilated very low birth weight preterm neonates. Cochrane Database Syst Rev 2007;4:CD001969.
  23. Sandri F, Plavka R, Simeoni U; CURPAP Advisory Board: The CURPAP study: an international randomized controlled trial to evaluate the efficacy of combining prophylactic surfactant and early nasal continuous positive airway pressure in very preterm infants. Neonatology 2008;94:60–62.
  24. Kinsella JP, Greenough A, Abman SH: Bronchopulmonary dysplasia. Lancet 2006;367:1421–1431.
  25. Morley CJ, Davis PG, Doyle LW, Brion LP, Hascoet JM, Carlin JB; COIN Trial Investigators: Nasal CPAP or intubation at birth for very preterm infants. N Engl J Med 2008;358:700–708; erratum in N Engl J Med 2008;358:1529.
  26. Wilson TT, Waters L, Patterson CC, McCusker CG, Rooney NM, Marlow N, Halliday HL: Neurodevelopmental and respiratory follow-up results at 7 years for children from the United Kingdom and Ireland enrolled in a randomized trial of early and late postnatal corticosteroid treatment, systemic and inhaled (the Open Study of Early Corticosteroid Treatment). Pediatrics 2006;117:2196–2205.
  27. Halliday HL, Ehrenkranz RA, Doyle LW: Early postnatal (<8 days) corticosteroids for preventing chronic lung disease in preterm infants. Cochrane Database Syst Rev 2009;1:CD001146.
  28. Shinwell ES, Karplus M, Reich D, Weintraub Z, Blazer S, Bader D, Yurman S, Dolfin T, Kogan A, Dollberg S, Arbel E, Goldberg M, Gur I, Naor N, Sirota L, Mogilner S, Zaritsky A, Barak M, Gottfried E: Early postnatal dexamethasone treatment and increased incidence of cerebral palsy. Arch Dis Child Fetal Neonatal Ed 2000;83:F177–F181.
  29. Walsh MC, Wilson-Costello D, Zadell A, Newman N, Fanaroff A: Safety, reliability, and validity of a physiologic definition of bronchopulmonary dysplasia. J Perinatol 2003;23:451–456.

Article / Publication Details

Received: February 10, 2009
Accepted: April 21, 2009
Published online: July 07, 2009
Issue release date: December 2009

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO


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