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Original Paper

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An Encapsulated Fruit and Vegetable Juice Concentrate Increases Skin Microcirculation in Healthy Women

De Spirt S.a · Sies H.a, b, d · Tronnier H.c · Heinrich U.c

Author affiliations

aInstitute of Biochemistry and Molecular Biology I, Faculty of Medicine, and bLeibniz Research Institute for Environmental Medicine, Heinrich Heine University, Düsseldorf, and cInstitute for Experimental Dermatology, University of Witten-Herdecke, Witten, Germany; dCollege of Science, King Saud University, Riyadh, Saudi Arabia

Corresponding Author

Prof. Ulrike Heinrich

Institute for Experimental Dermatology, University of Witten-Herdecke

Alfred-Herrhausen-Strasse 44

DE–58455 Witten (Germany)

Tel. +49 230 2282 6300, E-Mail ulrike.heinrich@uni-wh.de

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Skin Pharmacol Physiol 2012;25:2–8

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Background/Aim: Microcirculation in the dermis of the skin is important for nutrient delivery to this tissue. In this study, the effects of a micronutrient concentrate (Juice Plus+®; ‘active group’), composed primarily of fruit and vegetable juice powder, on skin microcirculation and structure were compared to placebo. Study Design/Methods: This 12-week study had a monocentric, double-blind placebo and randomized controlled design with two treatment groups consisting of 26 healthy middle-aged women each. The ‘oxygen to see’ device was used to evaluate microcirculation. Skin density and thickness were measured using ultrasound. Measurements for skin hydration (Corneometer®), transepidermal water loss and serum analysis for carotenoids and α-tocopherol were also performed. Results: By 12 weeks, microcirculation of the superficial plexus increased by 39%. Furthermore, skin hydration increased by 9% while skin thickness increased by 6% and skin density by 16% in the active group. In the placebo group, microcirculation decreased, and a slight increase in skin density was observed. Conclusion: Ingestion of a fruit- and vegetable-based concentrate increases microcirculation of the skin at 12 weeks of intervention and positively affects skin hydration, density and thickness.

© 2011 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 21, 2011
Accepted: June 06, 2011
Published online: August 05, 2011
Issue release date: December 2011

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP

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