An Encapsulated Fruit and Vegetable Juice Concentrate Increases Skin Microcirculation in Healthy WomenDe Spirt S.a · Sies H.a, b, d · Tronnier H.c · Heinrich U.c
aInstitute of Biochemistry and Molecular Biology I, Faculty of Medicine, and bLeibniz Research Institute for Environmental Medicine, Heinrich Heine University, Düsseldorf, and cInstitute for Experimental Dermatology, University of Witten-Herdecke, Witten, Germany; dCollege of Science, King Saud University, Riyadh, Saudi Arabia
Prof. Ulrike Heinrich
Institute for Experimental Dermatology, University of Witten-Herdecke
DE–58455 Witten (Germany)
Tel. +49 230 2282 6300, E-Mail firstname.lastname@example.org
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Background/Aim: Microcirculation in the dermis of the skin is important for nutrient delivery to this tissue. In this study, the effects of a micronutrient concentrate (Juice Plus+®; ‘active group’), composed primarily of fruit and vegetable juice powder, on skin microcirculation and structure were compared to placebo. Study Design/Methods: This 12-week study had a monocentric, double-blind placebo and randomized controlled design with two treatment groups consisting of 26 healthy middle-aged women each. The ‘oxygen to see’ device was used to evaluate microcirculation. Skin density and thickness were measured using ultrasound. Measurements for skin hydration (Corneometer®), transepidermal water loss and serum analysis for carotenoids and α-tocopherol were also performed. Results: By 12 weeks, microcirculation of the superficial plexus increased by 39%. Furthermore, skin hydration increased by 9% while skin thickness increased by 6% and skin density by 16% in the active group. In the placebo group, microcirculation decreased, and a slight increase in skin density was observed. Conclusion: Ingestion of a fruit- and vegetable-based concentrate increases microcirculation of the skin at 12 weeks of intervention and positively affects skin hydration, density and thickness.
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