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Original Report: Patient-Oriented, Translational Research

Survival of Dialysis Patients with Restless Legs Syndrome: A 15-Year Follow-Up Study

Baiardi S.a, b · Mondini S.a · Baldi Antognini A.c · Santoro A.d · Cirignotta F.a, b

Author affiliations

aNeurology Unit, S. Orsola-Malpighi Hospital, AOU Bologna, and bDIBINEM-Department of Biomedical and Neuromotor Sciences, cDepartment of Statistical Sciences, University of Bologna, and dNephrology Unit, S. Orsola-Malpighi Hospital, AOU Bologna, Bologna, Italy

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Am J Nephrol 2017;46:224-230

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: March 29, 2017
Accepted: June 22, 2017
Published online: September 05, 2017
Issue release date: September 2017

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

Background: Restless legs syndrome, also known as Willis/Ekbom disease (RLS/WED), is a sleep-related, sensorimotor disorder with a high prevalence among end-stage renal disease (ESRD) patients undergoing haemodialysis (HD) (about 15-40%). Whether RLS/WED in uremic patients influences cardiovascular morbidity and mortality remains a matter of controversy. The aim of this study was to evaluate the relationship of RLS/WED and mortality in a population of chronically dialyzed patients. Method: In 1996, we studied 128 patients with ESRD undergoing HD; 47 subjects (36.7%) complained RLS/WED symptoms. Fifteen years later we evaluated the mortality of this population. No clinical follow-up examination of the uremic population was made. The Kaplan-Maier curves in dialysis patients with or without RLS/WED (control group matched for age) were constructed for all-cause mortality and compared using log-rank test. Results: The Kaplan-Maier curves disclosed a lower mortality rate in the uremic patients with RLS/WED than in those without RLS/WED (p = 0.04). In our analysis, the mortality rate was not influenced by RLS/WED severity (p = 0.11) or gender (p = 0.15). No difference among the causes of death was found in the 2 groups. Conclusions: Our study suggests that mortality in ESRD patients is not influenced by concomitant RLS/WED. After a 15-year follow-up, survival rates in our cohort were significantly longer in uremic subjects with RLS/WED than in those without RLS/WED. Finally, we found no relationship between RLS/WED severity and mortality.

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: March 29, 2017
Accepted: June 22, 2017
Published online: September 05, 2017
Issue release date: September 2017

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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