Early Life Origins of Human Health and Disease
A Karger 'Publishing Highlights 1890–2015' title There is compelling evidence that many of the risks leading to the most frequent chronic diseases in adulthood originate in the earliest stages of life. Adverse environmental conditions in utero and during infancy can lead to negative health effects during the subsequent lifetime of the exposed individual. This book offers precious insights into the latest concepts and results from epidemiologic, clinical and basic studies in this burgeoning area of health care. The developmental origins of various diseases such as diabetes, obesity and cancer are examined, as well as the early programming of reproductive health and different organs. Attention is given to the impact of environmental factors such as nutrition and pollution, and the mediating genetic and epigenetic pathways are reviewed. A crucial point under discussion is the concept of environmental insults adversely affecting not only the exposed persons, but also their descendants. In addition, the economic consequences of a suboptimal start to life and the importance of preventive measures are stressed. This publication is of great value to anyone interested in health care, notably to specialists in obstetrics, pediatrics, internal medicine, obesity, diabetes and heart disease.
Download citation file:
Digital Version
Print Version
Table of Contents
-
1 - 10: Developmental Plasticity and the Developmental Origins of Health and DiseaseByPeter D. Gluckman;Peter D. GluckmanaLiggins Institute, The University of Auckland, Auckland, New Zealand;Search for other works by this author on:Mark A. HansonMark A. HansonbDevelopmental Origins of Health and Disease Centre, Institute of Developmental Sciences, University of Southampton, Southampton, UKSearch for other works by this author on:
-
11 - 20: Epigenetics and the Influence of Maternal DietByKaren A. Lillycrop;Karen A. LillycropaCell and Development, School of Biological Sciences,Search for other works by this author on:Graham C. BurdgeGraham C. BurdgecInstitute of Human Nutrition, University of Southampton, Southampton, UKSearch for other works by this author on:
-
21 - 28: The Economics of Developmental Origins of Health and Disease: Modelling the Benefit of a Healthy Start to LifeByS.M.B. MortonS.M.B. MortonaLiggins Institute,bSchool of Population Health, The University of Auckland, Auckland, New ZealandSearch for other works by this author on:
-
29 - 41: Nutritional Interventions in Mothers to Improve the Health of the Offspring – Are We Ready?ByCaroline H.D. Fall;Caroline H.D. FallaMRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK;Search for other works by this author on:Jane E. Harding;Jane E. HardingbDepartment of Neonatology, Liggins Institute, The University of Auckland, Auckland, New Zealand;Search for other works by this author on:Chittaranjan S. YajnikChittaranjan S. YajnikcDiabetes Unit, King Edward Memorial Hospital, Pune, IndiaSearch for other works by this author on:
-
42 - 51: Developmental Origins of Health and Disease: The Importance of Environmental ExposuresByRetha Newbold;Retha NewboldaDevelopmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Division of Intramural Research,Search for other works by this author on:Jerrold J. HeindelJerrold J. HeindelbDivision of Extramural Research and Training, National Institute of Environmental Health Sciences, Research Triangle Park, N.C., USASearch for other works by this author on:
-
52 - 64: Developmental Origins of Health and Disease across Generations – Theory, Observation, ExperimentByMatthew W. Gillman;Matthew W. GillmanaObesity Prevention Program, Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Mass., USA;Search for other works by this author on:George Davey Smith;George Davey SmithbMRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol,Search for other works by this author on:Mark A. Hanson;Mark A. HansoncDevelopmental Origins of Health and Disease Division, Institute of Developmental Sciences, Southampton General Hospital, Southampton, UK;Search for other works by this author on:Hamish G. SpencerHamish G. SpencerdNational Research Centre for Growth and Development, Department of Zoology, University of Otago, Dunedin, New ZealandSearch for other works by this author on:
-
65 - 77: Early Embryo Environment and Developmental PotentialByTom P. Fleming;Tom P. FlemingaSchool of Biological Sciences, University of Southampton, Southampton,Search for other works by this author on:Kevin D. Sinclair;Kevin D. SinclairbSchool of Biosciences, University of Nottingham, Sutton Bonington, UK;Search for other works by this author on:Karen L. KindKaren L. KindcResearch Centre for Reproductive Health, School of Agriculture, Food and Wine, University of Adelaide, Adelaide, S.A., AustraliaSearch for other works by this author on:
-
78 - 88: Early Environmental Influences on Lung Development: Implications for Lung Function and Respiratory Health throughout LifeByRichard Harding;Richard HardingaDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Vic,Search for other works by this author on:Ken Snibson;Ken SnibsonbSchool of Veterinary Science, University of Melbourne, Melbourne, Vic, Australia;Search for other works by this author on:Megan O’Reilly;Megan O’ReillyaDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Vic,Search for other works by this author on:Gert MaritzGert MaritzcDepartment of Medical Biosciences, University of the Western Cape, Bellville, South AfricaSearch for other works by this author on:
-
89 - 99: Development of the Fetal Hypothalamic-Pituitary-Adrenal-Placental Axis: Implications for Postnatal HealthByJohn Challis;John ChallisaDepartments of Physiology,bMedicine,cObstetrics and Gynecology, University of Toronto, Toronto, Ont., Canada;Search for other works by this author on:Kristin Connor;Kristin ConnoraDepartments of Physiology,Search for other works by this author on:Stephen Matthews;Stephen MatthewsaDepartments of Physiology,cObstetrics and Gynecology, University of Toronto, Toronto, Ont., Canada;Search for other works by this author on:Stephen J. Lye;Stephen J. LyeaDepartments of Physiology,cObstetrics and Gynecology, University of Toronto, Toronto, Ont., Canada;Search for other works by this author on:Isabella Caniggia;Isabella CaniggiacObstetrics and Gynecology, University of Toronto, Toronto, Ont., Canada;Search for other works by this author on:Felice Petraglia;Felice PetragliaeDepartment of Reproductive Medicine, University of Siena, Siena, Italy;Search for other works by this author on:Alberto Imperatore;Alberto ImperatoreeDepartment of Reproductive Medicine, University of Siena, Siena, Italy;Search for other works by this author on:Deborah M. Sloboda;Deborah M. SlobodagLiggins Institute, The University of Auckland, Auckland, New ZealandSearch for other works by this author on:Shaofu Li;Shaofu LidSchool of Women’s and Infants’ Health, the University of Western Australia, Perth, W.A., Australia;Search for other works by this author on:Thorsten Braun;Thorsten BraunfDepartment of Obstetrics, Charité Medical University, Berlin, Germany;Search for other works by this author on:John P. NewnhamJohn P. NewnhamdSchool of Women’s and Infants’ Health, the University of Western Australia, Perth, W.A., Australia;Search for other works by this author on:
-
100 - 112: Developmental Origins of Musculoskeletal DiseaseByCyrus Cooper;Cyrus CooperaMRC Epidemiology Resource Centre, Southampton General Hospital, School of Medicine, University of Southampton, Southampton,cInstitute of Musculoskeletal Sciences, University of Oxford, Oxford, UKSearch for other works by this author on:Avan Aihie Sayer;Avan Aihie SayeraMRC Epidemiology Resource Centre, Southampton General Hospital, School of Medicine, University of Southampton, Southampton,Search for other works by this author on:Gita Mishra;Gita MishrabMRC Lifelong Health and Ageing Unit, University College London, London,Search for other works by this author on:D. KuhD. KuhbMRC Lifelong Health and Ageing Unit, University College London, London,Search for other works by this author on:
-
113 - 122: Developmental Origins of Reproductive HealthByD.M. Sloboda;D.M. SlobodaaLiggins Institute, The University of Auckland, Auckland, New Zealand;Search for other works by this author on:R. Hart;R. HartbSchool of Women’s and Infants Health, The University of Western Australia,Search for other works by this author on:M. HickeyM. HickeybSchool of Women’s and Infants Health, The University of Western Australia,cWomen and Infants Research Foundation, King Edward Memorial Hospital, Perth, W.A., AustraliaSearch for other works by this author on:
-
123 - 132: Developmental Origins of Immune Tolerance: Pathways and InfluencesBySusan L. PrescottSusan L. PrescottSchool of Paediatrics and Child Health, University of Western Australia, Perth, W.A., AustraliaSearch for other works by this author on:
-
133 - 141: Developmental Programming of the KidneyByMark J. Nijland;Mark J. NijlandCenter for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Tex., USASearch for other works by this author on:Peter W. NathanielszPeter W. NathanielszCenter for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Tex., USASearch for other works by this author on:
-
142 - 163: Perinatal Appetite ProgrammingByMina Desai;Mina DesaiDepartment of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Geffen School of Medicine at UCLA, Los Angeles, Calif., USASearch for other works by this author on:Erin Keen-Rhinehart;Erin Keen-RhinehartDepartment of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Geffen School of Medicine at UCLA, Los Angeles, Calif., USASearch for other works by this author on:Michael G. RossMichael G. RossDepartment of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Geffen School of Medicine at UCLA, Los Angeles, Calif., USASearch for other works by this author on:
-
164 - 173: Fetal Programming of Type 2 DiabetesByAna Piekarz;Ana PiekarzInstitute of Metabolic Science, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UKSearch for other works by this author on:Susan E. OzanneSusan E. OzanneInstitute of Metabolic Science, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UKSearch for other works by this author on:
-
174 - 183: Developmental Origins of Diabetes: Interventional StrategiesByRebecca A. SimmonsRebecca A. SimmonsDepartment of Pediatrics, Children’s Hospital Philadelphia and University of Pennsylvania, Philadelphia, Pa., USASearch for other works by this author on:
-
184 - 192: Prenatal Risk Factors for Breast Cancer and Clues to the Underlying Biological Mechanisms from Animal and Human StudiesByRebecca Troisi;Rebecca TroisiaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Md.,bDepartment of Community and Family Medicine, Dartmouth Medical School, Hanover, N.H.,Search for other works by this author on:Isabel dos Santos Silva;Isabel dos Santos SilvadDepartment of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UKSearch for other works by this author on:Retha NewboldRetha NewboldcDevelopmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, N.C., USA;Search for other works by this author on:
-
193 - 204: The Offspring of Women with Severe Mental DisorderByV.A. Morgan;V.A. MorganaNeuropsychiatric Epidemiology Research Unit,bCentre for Clinical Research in Neuropsychiatry, School of Psychiatry and Clinical Neurosciences,Search for other works by this author on:J. McGrath;J. McGrathdQueensland Centre for Mental Health Research and Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia;Search for other works by this author on:C.M. Hultman;C.M. HultmaneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenSearch for other works by this author on:S. Zubrick;S. ZubrickcTelethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, W.A.,Search for other works by this author on:C. Bower;C. BowercTelethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, W.A.,Search for other works by this author on:M. Croft;M. CroftaNeuropsychiatric Epidemiology Research Unit,Search for other works by this author on:G. Valuri;G. ValuriaNeuropsychiatric Epidemiology Research Unit,Search for other works by this author on:A.V. JablenskyA.V. JablenskyaNeuropsychiatric Epidemiology Research Unit,bCentre for Clinical Research in Neuropsychiatry, School of Psychiatry and Clinical Neurosciences,Search for other works by this author on:
-
205 - 217: Approaches to Evaluate Gene-Environment Interactions Underlying the Developmental Origins of Health and DiseaseByCraig E. Pennell;Craig E. PennellaSchool of Women’s and Infants’ Health, andcObstetrics and Gynaecology, andSearch for other works by this author on:Lyle J. Palmer;Lyle J. PalmerbCentre for Genetic Epidemiology and Biostatistics, The University of Western Australia, Perth, W.A., Australia; Departments ofSearch for other works by this author on:Brian S. Knight;Brian S. KnightdPhysiology, University of Toronto,eSamuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont., Canada;Search for other works by this author on:Caroline Relton;Caroline ReltonfInstitute of Human Genetics, Newcastle University, Newcastle upon Tyne, UKSearch for other works by this author on:Stephen J. LyeStephen J. LyecObstetrics and Gynaecology, anddPhysiology, University of Toronto,eSamuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont., Canada;Search for other works by this author on: