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Allergy and the Nervous System

Editor(s): Bienenstock J. (Hamilton, Ont.) 

Status: available   
Publication year: 2012
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Digital Version: CHF 196.00, EUR 183.00, USD 231.00
Print Version: CHF 196.00, EUR 183.00, USD 231.00
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This book belongs to
Chemical Immunology and Allergy , Vol. 98
Editor(s): Renz H. (Marburg) 
XII + 272 p., 51 fig., 4 tab., hard cover, 2012
Status: available   
ISSN: 1660-2242
e-ISSN: 1662-2898

Read the reviews


‘John Bienenstock and his co-workers have been among the first researchers to stress the relevance of neuroimmune interactions in allergic diseases with their pioneer studies on the anatomical contacts between mast cells and nerves as well as on the role of neurotrophins in modulating the mast cell release of inflammatory cytokines. Therefore, no one better than John Bienenstock could have edited this 272 pages book of the prestigious series Chemical Immunology and Allergy.
In fact, the Editor has been able to select for the 15 chapters of the volume the most relevant topics in neuroendocrine immunology and the most qualified experts to address them.
The book covers with the same accuracy both basic aspects of the structure and function of the neuroimmune system and translational aspects, with special relevance to lung and skin diseases……
In spite of the high and increasing number of papers in the area of neuroimmunology, this book is quite unique in this field, by providing a comprehensive and up-dated review of all major research and clinical issues for both experts in this area and those who wish to discover the fascinating world of body-mind interactions in allergy and asthma.’

Sergio Bonini
Website of the EAACI (European Academy of Allergy and Clinical Immunology)

Towards a holistic way of understanding and treating asthma and allergy
In recent decades, it has become increasingly clear that the immune and nervous systems communicate with each other in a bidirectional way. The role of chronic stress in allergic disease and inflammation has been confirmed and raises the important question of how psychosocial factors influence the outcome of allergic conditions.
This book explains the roles of the autonomic, peripheral and central nervous systems in allergy and asthma. With contributions from leading authorities - both clinicians and basic researchers - it covers a wide range of topics from psychology over epigenetics to brain imaging. The 15 invited reviews discuss topics such as the role of stress in allergy and asthma, the concept of programming in utero and in childhood and adulthood, the significance of neurotrophins, and the involvement of the nervous system in the lung in asthma and lung inflammation. The interactions between mast cells and the nervous system are examined as well as the role of the gut microbiome in regulating the hypothalamic-pituitary-adrenal axis and the stress response. Further chapters are devoted to neural and behavioral changes associated with food allergy, the role of the neuroendocrine system in the skin, and the way in which itch is processed by the brain.
Unique in its field, this valuable volume is recommended reading not only for allergologists, psychologists specializing in allergy and somatic manifestations, respirologists and asthma researchers, but for anyone interested in psychoneuroimmunology.