Puberty from Bench to Clinic: Lessons for Clinical Management of Pubertal Disorders
Puberty is a unique paradigm for the understanding of gene-environment interaction and developmental programming. Therefore, normal and abnormal pubertal development can be divided and examined in three sections: the role of genetic factors, the role of environmental factors (including nutrition) and therapeutic issues in disorders of puberty. Dealing with all of these sections and framed along current key concepts in pediatric endocrinology, experts share their view on critical issues such as weighting of genetic versus environmental factors or the impact of environmental factors in relation to critical periods in development. Not only showing the consensus and controversial issues in the various areas, each chapter presents lessons for clinical management in an attempt to link basic research, physiology and pathophysiology with the clinical management of pubertal disorders. Puberty from Bench to Clinic bridges up-to-date concepts from animal and human physiology and pathology towards a better understanding and management of pubertal disorders, making it a unique resource for researchers in the field of development and reproduction, clinical scientists and practitioners in neuro-, pediatric and adolescent endocrinology as well as gynecology.
Download citation file:
Digital Version
Print Version
Table of Contents
-
1 - 16: The Emerging Role of Epigenetics in the Regulation of Female PubertyByAlejandro Lomniczi;Alejandro LomnicziDivision of Neuroscience, Oregon National Primate Research Center/Oregon Health and Science University, Beaverton, Oreg., USASearch for other works by this author on:Sergio R. OjedaSergio R. OjedaDivision of Neuroscience, Oregon National Primate Research Center/Oregon Health and Science University, Beaverton, Oreg., USASearch for other works by this author on:
-
17 - 35: Normal Variation in Pubertal Timing: Genetic Determinants in Relation to Growth and AdiposityByRuben H. Willemsen;Ruben H. WillemsenDepartment of Paediatrics and Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UKSearch for other works by this author on:David B. DungerDavid B. DungerDepartment of Paediatrics and Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UKSearch for other works by this author on:
-
36 - 49: Genetics of Hypogonadotropic HypogonadismByA. Kemal Topaloglu;A. Kemal TopalogluaDivision of Pediatric Endocrinology, Faculty of Medicine, andbDepartment of Biotechnology, Institute of Sciences, Cukurova University, Adana, TurkeySearch for other works by this author on:L. Damla KotanL. Damla KotanbDepartment of Biotechnology, Institute of Sciences, Cukurova University, Adana, TurkeySearch for other works by this author on:
-
50 - 71: Sexual Precocity - Genetic Bases of Central Precocious Puberty and Autonomous Gonadal ActivationByDelanie Bulcão Macedo;Delanie Bulcão MacedoUnidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Hospital das Clínicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, BrazilSearch for other works by this author on:Letícia Ferreira Gontijo Silveira;Letícia Ferreira Gontijo SilveiraUnidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Hospital das Clínicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, BrazilSearch for other works by this author on:Danielle Souza Bessa;Danielle Souza BessaUnidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Hospital das Clínicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, BrazilSearch for other works by this author on:Vinicius Nahime Brito;Vinicius Nahime BritoUnidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Hospital das Clínicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, BrazilSearch for other works by this author on:Ana Claudia LatronicoAna Claudia LatronicoUnidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular/LIM42, Hospital das Clínicas, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, BrazilSearch for other works by this author on:
-
72 - 86: Congenital Hypogonadotropic Hypogonadism: A Trait Shared by Several Complex Neurodevelopmental DisordersByNicolas de Roux;Nicolas de RouxaInserm, U1141, Univ Paris Diderot, DHU PROTECT, Sorbonne Paris Cité, Hôpital Robert Debré,bAP-HP, Laboratoire de Biochimie, andSearch for other works by this author on:Jean-Claude Carel;Jean-Claude CarelaInserm, U1141, Univ Paris Diderot, DHU PROTECT, Sorbonne Paris Cité, Hôpital Robert Debré,cAP-HP, Service d'Endocrinologie Diabétologie Pédiatrique et Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Hôpital Robert Debré, Paris, FranceSearch for other works by this author on:Juliane LégerJuliane LégeraInserm, U1141, Univ Paris Diderot, DHU PROTECT, Sorbonne Paris Cité, Hôpital Robert Debré,cAP-HP, Service d'Endocrinologie Diabétologie Pédiatrique et Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Hôpital Robert Debré, Paris, FranceSearch for other works by this author on:
-
87 - 121: Animal Modeling of Early Programming and Disruption of Pubertal MaturationByJuan M. Castellano;Juan M. CastellanoDepartment of Cell Biology, Physiology and Immunology, University of Córdoba, CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, and Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofia, Córdoba, SpainSearch for other works by this author on:Manuel Tena-SempereManuel Tena-SempereDepartment of Cell Biology, Physiology and Immunology, University of Córdoba, CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, and Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofia, Córdoba, SpainSearch for other works by this author on:
-
122 - 133: Contemporary Trends in Onset and Completion of Puberty, Gain in Height and AdiposityByFrank M. Biro;Frank M. BiroaDivision of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA;Search for other works by this author on:Wieland KiessWieland KiessbHospital for Children and Adolescents, Department of Women and Child Health, University Hospitals, University of Leipzig, Leipzig, GermanySearch for other works by this author on:
-
134 - 152: Consequences of Early Life Programing by Genetic and Environmental Influences: A Synthesis Regarding Pubertal TimingByChristian L. Roth;Christian L. RothaSeattle Children's Hospital Research Institute, andbDepartment of Pediatrics, University of Washington, Seattle, Wash., USASearch for other works by this author on:Sara DiVallSara DiVallbDepartment of Pediatrics, University of Washington, Seattle, Wash., USASearch for other works by this author on:
-
153 - 173: Nutritional and Pubertal DisordersByM. Teresa Muñoz-Calvo;M. Teresa Muñoz-CalvoDepartments of Endocrinology and Pediatrics and Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Department of Pediatrics, CIBEROBN Fisiopatología de la obesidad y nutrición, and Programme of Obesity in Childhood and Adolescence, Instituto de Salud Carlos III, Madrid, SpainSearch for other works by this author on:Jesús ArgenteJesús ArgenteDepartments of Endocrinology and Pediatrics and Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Department of Pediatrics, CIBEROBN Fisiopatología de la obesidad y nutrición, and Programme of Obesity in Childhood and Adolescence, Instituto de Salud Carlos III, Madrid, SpainSearch for other works by this author on:
-
174 - 184: Current Changes in Pubertal Timing: Revised Vision in Relation with Environmental Factors Including Endocrine DisruptorsByAnne-Simone Parent;Anne-Simone ParentaDevelopmental Neuroendocrinology Unit, GIGA Neurosciences, University of Liège, Liège, andbDepartment of Pediatrics, CHU de Liège, Chênée, BelgiumSearch for other works by this author on:Delphine Franssen;Delphine FranssenaDevelopmental Neuroendocrinology Unit, GIGA Neurosciences, University of Liège, Liège, andSearch for other works by this author on:Julie Fudvoye;Julie FudvoyeaDevelopmental Neuroendocrinology Unit, GIGA Neurosciences, University of Liège, Liège, andbDepartment of Pediatrics, CHU de Liège, Chênée, BelgiumSearch for other works by this author on:Anneline Pinson;Anneline PinsonaDevelopmental Neuroendocrinology Unit, GIGA Neurosciences, University of Liège, Liège, andSearch for other works by this author on:Jean-Pierre BourguignonJean-Pierre BourguignonaDevelopmental Neuroendocrinology Unit, GIGA Neurosciences, University of Liège, Liège, andbDepartment of Pediatrics, CHU de Liège, Chênée, BelgiumSearch for other works by this author on:
-
185 - 197: Sex Steroid and Gonadotropin Treatment in Male Delayed PubertyBySasha Howard;Sasha HowardCentre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UKSearch for other works by this author on:Leo DunkelLeo DunkelCentre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UKSearch for other works by this author on:
-
198 - 213: Sex Steroid Replacement Therapy in Female Hypogonadism from Childhood to Young AdulthoodByEnsio Norjavaara;Ensio NorjavaaraaDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Göteborg,Search for other works by this author on:Carina Ankarberg-Lindgren;Carina Ankarberg-LindgrenaDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Göteborg,Search for other works by this author on:Berit KriströmBerit KriströmbInstitute of Clinical Science/Pediatrics, Umeå University, Umeå, SwedenSearch for other works by this author on:
-
214 - 229: Gonadotropin-Releasing Hormone Agonist Treatment in Sexual PrecocityByCatherine Pienkowski;Catherine PienkowskiUnité d'Endocrinologie, Génétique et Gynécologie Médicale, Hôpital des Enfants, Toulouse, FranceSearch for other works by this author on:Maithé TauberMaithé TauberUnité d'Endocrinologie, Génétique et Gynécologie Médicale, Hôpital des Enfants, Toulouse, FranceSearch for other works by this author on:
-
230 - 239: Treatment of Peripheral Precocious PubertyByMelissa Schoelwer;Melissa SchoelwerSection of Pediatric Endocrinology, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Ind., USASearch for other works by this author on:Erica A. EugsterErica A. EugsterSection of Pediatric Endocrinology, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Ind., USASearch for other works by this author on:
-
240 - 255: Consultation for Disordered Puberty: What Do Adolescent Medicine Patients Teach Us?ByPierre-André Michaud;Pierre-André MichaudaFaculty of Biology and Medicine, University of Lausanne, Bussigny,Search for other works by this author on:Anne-Emmanuelle AmbresinAnne-Emmanuelle AmbresinbInterdisciplinary Division for Adolescent Health, University Hospital/CHUV, Lausanne, SwitzerlandSearch for other works by this author on: